4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID

Names

[ Name ]:
4,4'-DIISOTHIOCYANATOSTILBENE-2,2'-DISULFONIC ACID

[Synonym ]:
dids
4,4'-Diisothiocyanostilbene-2,2'-disulfonic acid
4,4'-diisothiocyanato-stilbene-2,2'-disulfonic acid
trans-4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid
4,4'-diisothiocyanato-2,2'-stilbenedisulfoneic acid
4,4'-diisothiocyanostilbene-2-2'-disulphonic acid
5-isothiocyanato-2-[(E)-2-(4-isothiocyanato-2-sulfophenyl)ethenyl]benzenesulfonic acid
4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic acid

Biological Activity

[Description]:

DIDS is a potent RAD51 inhibitor. DIDS inhibits the RAD51-mediated homologous pairing and strand-exchange reactions. DIDS inhibits anion exchange and binding to the red blood cell membrane[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> RAD51

[In Vitro]

DIDS (0-10 μM) 抑制 RAD51 介导的链交换[1]。 DIDS (0-20 μM) 通过 RAD51 抑制 DNA 结合[1]。 DIDS (10 μM; 0-60 分钟) 在 DNA 不存在的情况下刺激 RAD51 的 ATP 水解活性[1]。

[References]

[1]. Ishida T, et, al. DIDS, a chemical compound that inhibits RAD51-mediated homologous pairing and strand exchange. Nucleic Acids Res. 2009 Jun;37(10):3367-76.

[2]. Lepke S, et, al. A study of the relationship between inhibition of anion exchange and binding to the red blood cell membrane of 4,4'-diisothiocyano stilbene-2,2'-disulfonic acid (DIDS) and its dihydro derivative (H2DIDS). J Membr Biol. 1976 Oct 20;29(1-2):147-77.

Chemical & Physical Properties

[ Density]:
1.54g/cm3

[ Melting Point ]:
>400ºC

[ Molecular Formula ]:
C₁₆H₁₀N₂O₆S₄

[ Molecular Weight ]:
454.52000

[ Exact Mass ]:
453.94200

[ PSA ]:
214.40000

[ LogP ]:
5.98060

[ Index of Refraction ]:
1.693

Safety Information

[ HS Code ]:
2930909090

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%