2-hydroxy-1-naphthalaldehyde salicyloylhydrazone

Names

[ Name ]:
2-hydroxy-1-naphthalaldehyde salicyloylhydrazone

[Synonym ]:
5,6-benzosalicylidene-salicyloyl hydrazide
Benzoic acid,2-hydroxy-,((2-hydroxy-1-naphthalenyl)methylene)hydrazide
1-(2-hydroxybenzoyl)-2-(2-hydroxynaphthal)hydrazine
2-Hydroxy-1-naphthalaldehyde salicyloylhydrazone
2-hydroxy-1-naphthaldehyde salicyloylhydrazone
2-hydroxy-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide
2-hydroxy-N'-((2-hydroxy-naphthalen-1-yl)methylene)benzohydrazide
N'-[1-(2-hydroxynaphthyl)ethylidene]-2-hydroxybenzohydrazide
5,6-benzosalicylidene salicyloyl hydrazone
HNASH

Biological Activity

[Description]:

(E/Z)-NSAH is an isoform of NSAH (HY-114503), which is reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

[References]

[1]. Md Faiz Ahmad, et al. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8241-8246.

Chemical & Physical Properties

[ Density]:
1.4g/cm3

[ Boiling Point ]:
526.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₄N₂O₃

[ Molecular Weight ]:
306.32

[ Flash Point ]:
272.1ºC

[ Exact Mass ]:
306.10000

[ PSA ]:
81.92000

[ LogP ]:
3.22930

[ Index of Refraction ]:
1.734

Safety Information

[ HS Code ]:
2928000090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%