3,6-oxo-1,2,3,6-tetrahydrophthalic anhydride

Names

[ Name ]:
3,6-oxo-1,2,3,6-tetrahydrophthalic anhydride

[Synonym ]:
4,10-Dioxatricyclo[5.2.1.0]dec-8-ene-3,5-dione
3,6-Endoxo-1,2,3,6-tetrahydrophthalic Anhydride
3,6-oxo-1,2,3,6-tetrahydrophthalic anhydride
4,7-Epoxyisobenzofuran-1,3-dione, 3a,4,7,7a-tetrahydro-
4,10-Dioxa-tricyclo[5.2.1.0]dec-8-ene-3,5-dione
4,10-dioxatricyclo[5.2.1.0(2,6)]dec-8-ene-3,5-dione
7-Oxabicyclo[2.2.1]-5-heptene-2,3-dicarboxylic Anhydride

Biological Activity

[Description]:

4,10-Dioxatri cyclo[5.2. 1.02.6]dec-8-ene-3,5-dione is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
372.0±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₆O₄

[ Molecular Weight ]:
166.13

[ Flash Point ]:
172.2±27.9 °C

[ Exact Mass ]:
166.026611

[ PSA ]:
52.60000

[ LogP ]:
-0.77

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.584

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2932999099

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%