4-Thiodeoxyuridine

Names

[ Name ]:
4-Thiodeoxyuridine

[Synonym ]:
desoxysesbanine
4-thiodeoxyuridine
2'-deoxy-4-thiouridine
Deoxythiouridine
DEOXYSESBANINE
4-thio-2'-deoxyuridine

Biological Activity

[Description]:

4-Thio-2’-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.59g/cm3

[ Melting Point ]:
169 °C

[ Molecular Formula ]:
C₉H₁₂N₂O₄S

[ Molecular Weight ]:
244.27

[ Exact Mass ]:
244.05200

[ PSA ]:
119.57000

[ Index of Refraction ]:
1.697

4-Thiodeoxyuridine

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds