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Chlordantoin

Names

[ CAS No. ]:
5588-20-5

[ Name ]:
Chlordantoin

[Synonym ]:
Clodantoina [INN-Spanish]
Sporostacin
EINECS 226-995-3
Chlordantoin
Clodantoin
Clodantoinum [INN-Latin]
Clodantocidum
Clodantoine [INN-French]

Biological Activity

[Description]:

Chlordantoin is an antifungal drug which can be used to treat vaginal candidiasis.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Fungal
Research Areas >> Infection

[Target]

Fungal[1]


[References]

[1]. Morris DF, et al. Miconazole nitrate compared with chlordantoin in the treatment of vaginal candidiasis. Br J Vener Dis. 1975 Apr;51(2):123-4.


[Related Small Molecules]

Cycloheximide | Hygromycin B | Cancidas | 5-Flucytosine | Posaconazole | Terbinafine | Ciclopirox | Isavuconazole | Anidulafungin | Clotrimazole | Clioquinol | Miconazole Nitrate | Pimaricin | Ascomycin | Econazole (nitrate)

Chemical & Physical Properties

[ Density]:
1.39g/cm3

[ Molecular Formula ]:
C11H17Cl3N2O2S

[ Molecular Weight ]:
347.68900

[ Exact Mass ]:
346.00800

[ PSA ]:
74.71000

[ LogP ]:
4.36580

[ Index of Refraction ]:
1.562

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MU2400000
CHEMICAL NAME :
Hydantoin, 5-(1-ethylpentyl)-3-((trichloromethyl)thio)-
CAS REGISTRY NUMBER :
5588-20-5
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C11-H17-Cl3-N2-O2-S
MOLECULAR WEIGHT :
347.71
WISWESSER LINE NOTATION :
T5MVNVTJ CSXGGG EY4&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1165 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 11,73,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
86 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 11,73,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
>400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 11,73,1961