palbociclib
Names
[ CAS No. ]:
571190-30-2
[ Name ]:
palbociclib
[Synonym ]:
PD0332991
PD332991
6-acetyl-8-cyclopentyl-5-methyl-2-[(5-piperazin-1-ylpyridin-2-yl)amino]pyrido[2,3-d]pyrimidin-7-one
Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-
Palbociclib
6-Acetyl-8-cyclopentyl-5-methyl-2-{[5-(1-piperazinyl)-2-pyridinyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
UNII-G9ZF61LE7G
PD 0332991
6-acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one
Ibrance
Biological Activity
[Description]:
[Related Catalog]:
[Target]
Cdk4/cyclin D3:9 nM (IC50)
Cdk4/cyclin D1:11 nM (IC50)
Cdk6/cyclin D2:16 nM (IC50)
DYRK1A:2000 nM (IC50)
MAPK:8000 nM (IC50)
[In Vitro]
[In Vivo]
[Kinase Assay]
[Cell Assay]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
711.5±70.0 °C at 760 mmHg
[ Melting Point ]:
200ºC
[ Molecular Formula ]:
C24H29N7O2
[ Molecular Weight ]:
447.533
[ Flash Point ]:
384.1±35.7 °C
[ Exact Mass ]:
447.238281
[ PSA ]:
105.04000
[ LogP ]:
0.99
[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C
[ Index of Refraction ]:
1.648
Safety Information
[ Hazard Codes ]:
T+
[ RIDADR ]:
2811.0