ranimustine
Names
[ CAS No. ]:
58994-96-0
[ Name ]:
ranimustine
[Synonym ]:
Cymerin
MCNU
MFCD00866369
Thymerin
RCL L16,919-6
1-(2-chloroethyl)-1-nitroso-3-[[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-methoxy-oxan-2-yl]methyl]urea
Ranomustine
Biological Activity
[Description]:
[Related Catalog]:
[In Vivo]
Chemical & Physical Properties
[ Density]:
1.69 g/cm3
[ Molecular Formula ]:
C10H18ClN3O7
[ Molecular Weight ]:
327.71900
[ Exact Mass ]:
327.08300
[ PSA ]:
140.92000
[ Index of Refraction ]:
1.616
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LZ5910000
- CHEMICAL NAME :
- Glucopyranoside, methyl-6-((((2-chloroethyl)nitrosoamino)carbonyl)amin o)-6-deoxy-, alpha-D-
- CAS REGISTRY NUMBER :
- 58994-96-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C10-H18-Cl-N3-O7
- MOLECULAR WEIGHT :
- 327.76
- WISWESSER LINE NOTATION :
- T6OTJ BO1 CQ DQ EQ F1MVNNO&2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 46400 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 37 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 31800 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 45700 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 39 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 41200 ug/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 5 mg/kg
- SEX/DURATION :
- female 5 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- AMKUDT Acta Medica Kinki University. (Kinki Univ. Medical Assoc., 380 Nishiyama, Sayama-cho, Minami-kawachi-gun, Osaka-fu, Japan) V.1- 1976- Volume(issue)/page/year: 11,57,1986
Safety Information
[ Hazard Codes ]:
T
[ Risk Phrases ]:
R25:Toxic if swallowed. R41:Risk of serious damage to eyes. R43:May cause sensitization by skin contact.
[ Safety Phrases ]:
S26-S36/37/39-S45
[ RIDADR ]:
UN 2811 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
XU7700000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1