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a-D-Xylofuranose,1,2-O-(1-methylethylidene)-, 5-benzoate

Names

[ CAS No. ]:
6022-96-4

[ Name ]:
a-D-Xylofuranose,1,2-O-(1-methylethylidene)-, 5-benzoate

[Synonym ]:
(4-hydroxy-7,7-dimethyl-2,6,8-trioxabicyclo[3.3.0]oct-3-yl)methylbenzoate
5-O-benzoyl-1,2-O-isopropylidene-D-xylofuranose
α-D-Xylofuranose, 1,2-O-(1-methylethylidene)-, 5-benzoate
5-O-Benzoyl-1,2-O-isopropylidene-α-D-xylofuranose
[(3aR,5R,6S,6aR)-6-Hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methyl benzoate
[(3aR,5R,6S,6aR)-6-Hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methylbenzoat

Biological Activity

[Description]:

5-O-Benzoyl-1,2-di-O-isopropylidene-alpha-D-xylofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
432.0±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H18O6

[ Molecular Weight ]:
294.30

[ Flash Point ]:
159.2±20.8 °C

[ Exact Mass ]:
294.110352

[ PSA ]:
74.22000

[ LogP ]:
3.04

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.533

Synthetic Route

Precursor & DownStream


Related Compounds