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Valopicitabine dihydrochloride

Names

[ CAS No. ]:
640725-71-9

[ Name ]:
Valopicitabine dihydrochloride

[Synonym ]:
Valopicitabine dihydrochloride
NM283

Biological Activity

[Description]:

Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable prodrug of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HCV
Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Signaling Pathways >> Metabolic Enzyme/Protease >> HCV Protease

[In Vivo]

Valopicitabine (NM283) (100 mg/kg; oral administration; Sprague-Dawley Rats) dihydrochloride shows the Cmax, AUC, t1/2, and tmax were 3.624 μg/mL, 8.95 μg h/mL, 0.64 hours and 1 hour, respectively[2].

[References]

[1]. Liu-Young G, et al. Hepatitis C protease and polymerase inhibitors in development. AIDS Patient Care STDS. 2008;22(6):449-457.

[2]. Pierra C, et al. Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. J Med Chem. 2006;49(22):6614-6620.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H26Cl2N4O6

[ Molecular Weight ]:
429.30

[ Exact Mass ]:
428.12300

[ PSA ]:
163.91000

[ LogP ]:
1.00800

Related Compounds