punicalin

Names

[ Name ]:
punicalin

[Synonym ]:
punicalin
(10S,11R,12R,15R)-3,4,5,11,12,13,21,22,23,26,27,38,39-Tridecahydroxy-9,14,17,29,36-pentaoxaoctacyclo[29.8.0.0.0.0.0.0.0]nonatriaconta-1(39),2,4,6,19,21,23,25,27 ,31,33,37-dodecaene-8,18,30,35-tetrone
gn-30

Biological Activity

[Description]:

Punicalin is a hydrolyzable tannin isolated from Punica granatum L. or the leaves of Terminalia catappa L.. Punicalin is a anti-hepatitis B virus (HBV) agent and has anti-inflammatory activity[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

Research Areas >> Inflammation/Immunology

[References]

[1]. Lin CC, et al. Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats. Am J Chin Med. 1999;27(3-4):371-6.

[2]. Liu C, et al. Identification of hydrolyzable tannins (punicalagin, punicalin and geraniin) as novel inhibitors of hepatitis B virus covalently closed circular DNA. Antiviral Res. 2016 Oct;134:97-107.

Chemical & Physical Properties

[ Density]:
2.1±0.1 g/cm3

[ Boiling Point ]:
1559.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₄H₂₂O₂₂

[ Molecular Weight ]:
782.525

[ Flash Point ]:
484.7±27.8 °C

[ Exact Mass ]:
782.060242

[ PSA ]:
385.24000

[ LogP ]:
1.24

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.872

[ Storage condition ]:
-20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Effects of pomegranate chemical constituents/intestinal microbial metabolites on CYP1B1 in 22Rv1 prostate cancer cells.

J. Agric. Food Chem. 57(22) , 10636-44, (2009)

The cytochrome P450 enzyme, CYP1B1, is an established target in prostate cancer chemoprevention. Compounds inhibiting CYP1B1 activity are contemplated to exert beneficial effects at three stages of pr...

A new method of standartization of health-promoting pomegranate fruit (Punica granatum) extract.

Georgian Med. News (140) , 70-7, (2006)

This study analyzes the major phenolic constituents of pomegranate fruit juice and pericarp feedstock, and dry extracts thereof, using high-performance liquid chromatography. Pomegranate pericarp was ...

Antioxidant and hepatoprotective effects of punicalagin and punicalin on acetaminophen-induced liver damage in rats.

Phytother Res. 15(3) , 206-12, (2001)

Punicalagin and punicalin were isolated from the leaves of Terminalia catappa L., a Combretaceous plant distributed throughout tropical and subtropical beaches, which is used for the treatment of derm...