5,6,7,15-tetrahydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaen-13-one

Names

[ Name ]:
5,6,7,15-tetrahydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaen-13-one

[Synonym ]:
Antibiotic LL Z1640-4

Biological Activity

[Description]:

LL-Z1640-4 is a potent p38/JNK signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and JNK activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

Signaling Pathways >> MAPK/ERK Pathway >> JNK

[In Vitro]

LL-Z1640-4 markedly restores the number of cells in migration and invasion decreased by siMLK4, and significantly up-regulates expression of MMP2 and Vimentin[2].

[References]

[1]. Ellestad George A, et al. New zearalenone related macrolides and isocoumarins from an unidentified fungus. The Journal of Organic Chemistry, 1978,43(12):2339–2343.

[2]. Li Y, Zuo H, Wang H, Hu A. Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling. Biomed Pharmacother. 2019 Aug;116:108749.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₄O₇

[ Molecular Weight ]:
364.39000

[ Exact Mass ]:
364.15200

[ PSA ]:
116.45000

[ LogP ]:
1.39200

5,6,7,15-tetrahydroxy-17-methoxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),2,8,15,17-pentaen-13-one

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream