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Esculentoside H

Names

[ CAS No. ]:
66656-92-6

[ Name ]:
Esculentoside H

[Synonym ]:
β-D-Glucopyranose, 1-O-[(2β,3β,5ξ,18α)-3-[(4-O-β-D-glucopyranosyl-β-D-xylopyranosyl)oxy]-2,23-dihydroxy-29-methoxy-28,29-dioxoolean-12-en-28-yl]-
1-O-[(2β,3β,5ξ,18α)-3-{[4-O-(β-D-Glucopyranosyl)-β-D-xylopyranosyl]oxy}-2,23-dihydroxy-29-methoxy-28,29-dioxoolean-12-en-28-yl]-β-D-glucopyranose
Esculentoside H

Biological Activity

[Description]:

Esculentoside H (EsH) is a water-soluble saponin isolated and purified from the root extract of perennial plant Phytolacca esculenta[1]. Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease[2].Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the JNK1/2 and NF-κB signaling-mediated matrix metalloproteinases-9 (MMP-9) expression[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> JNK

[References]

[1]. Ha SH, et al. Esculentoside H inhibits colon cancer cell migration and growth through suppression of MMP-9 gene expression via NF-kB signaling pathway. J Cell Biochem. 2019 Jun;120(6):9810-9819.

[2]. Hu ZL, et al. Effect of esculentoside H on release of tumor necrosis factor from mouse peritoneal macrophages. Zhongguo Yao Li Xue Bao. 1993 Nov;14(6):550-2.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
1042.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C48H76O21

[ Molecular Weight ]:
989.104

[ Flash Point ]:
295.3±27.8 °C

[ Exact Mass ]:
988.487915

[ LogP ]:
1.78

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.635

Related Compounds