Sirt1/2-IN-2

Names

[ CAS No. ]:
670267-73-9

[ Name ]:
Sirt1/2-IN-2

Biological Activity

[Description]:

Sirt1/2-IN-2 (compound hsa55) is a dual inhibitor of SIRT1/2 with IC50s of 1.8 μM (SIRT1) and 2.4 μM (SIRT2), respsectivley. Sirt1/2-IN-2 completely blocks p53 deacetylation, and increase of p53 and α-tubulin acetylation. Sirt1/2-IN-2 induces apoptosis and shows anti-proliferation activity against human leukemia cell lines[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin
Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[Target]

IC50: 1.8 μM (SIRT1), 2.4 μM (SIRT2), 65 μM (SIRT3)[1]


[References]

[1]. Cai H, et al. Discovery of Novel SIRT1/2 Inhibitors with Effective Cytotoxicity against Human Leukemia Cells. J Chem Inf Model. 2023 Aug 14;63(15):4780-4790.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H14N4O3S2

[ Molecular Weight ]:
398.46

Related Compounds