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Kif15-IN-1

Names

[ CAS No. ]:
672926-32-8

[ Name ]:
Kif15-IN-1

[Synonym ]:
5-Thiazolecarboxylic acid, 2-[[(2S)-2-(1,4-dihydro-2,4-dioxo-3(2H)-quinazolinyl)-3-methyl-1-oxobutyl]amino]-4-methyl-, ethyl ester
Ethyl 2-{[(2S)-2-(2,4-dioxo-1,4-dihydro-3(2H)-quinazolinyl)-3-methylbutanoyl]amino}-4-methyl-1,3-thiazole-5-carboxylate

Biological Activity

[Description]:

Kif15-IN-1 is an inhibitor of the mitotic kinesin Kif15, and is used for the research of cellular proliferative diseases.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Kinesin
Signaling Pathways >> Cytoskeleton >> Kinesin
Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Research Areas >> Inflammation/Immunology

[Target]

KIF15


[In Vitro]

Kif15-IN-1 (Compound 10) is an inhibitor of the mitotic kinesin Hs Kif15, with the potential activities against cellular proliferative diseases such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and inflammation[1].

[References]

[1]. Preparation of quinazolinediones as Kif15 kinesin inhibitors for treating cellular proliferative disorders. Pat. Appl. Publ. (2004), US 20040053948 A1 20040318.


[Related Small Molecules]

ARRY-520 | GSK-923295 | Ispinesib | Monastrol | Kif15-IN-2 | Litronesib | CW-069 | K 858 | SB743921 | AZ82 | Eg5 Inhibitor V, trans-24 | EMD534085 | Paprotrain

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C20H22N4O5S

[ Molecular Weight ]:
430.478

[ Exact Mass ]:
430.131104

[ LogP ]:
3.73

[ Index of Refraction ]:
1.619

[ Storage condition ]:
2-8℃

Related Compounds