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Kif15-IN-2

Names

[ CAS No. ]:
672926-33-9

[ Name ]:
Kif15-IN-2

[Synonym ]:
3(2H)-Quinazolineacetamide, 1,4-dihydro-α-(1-methylethyl)-N-[4-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)-2-thiazolyl]-2,4-dioxo-, (αS)-
(2S)-2-(2,4-Dioxo-1,4-dihydro-3(2H)-quinazolinyl)-3-methyl-N-[4-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)-1,3-thiazol-2-yl]butanamide

Biological Activity

[Description]:

Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15, and is used for the research of cellular proliferative diseases.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Kinesin
Signaling Pathways >> Cytoskeleton >> Kinesin
Research Areas >> Cardiovascular Disease
Research Areas >> Inflammation/Immunology
Research Areas >> Cancer

[Target]

KIF15


[In Vitro]

Kif15-IN-2 (Compound 14) is an inhibitor of the mitotic kinesin Hs Kif15, with the potential activities against cellular proliferative diseases such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders and inflammation[1].

[References]

[1]. Quinazolinedione derivatives useful for treating cellular proliferative disorders and disorders associated with Kif15 kinesin activity are described. US 20040053948 A1.


[Related Small Molecules]

ARRY-520 | GSK-923295 | Ispinesib | Kif15-IN-1 | Monastrol | Litronesib | CW-069 | K 858 | SB743921 | AZ82 | Eg5 Inhibitor V, trans-24 | EMD534085 | Paprotrain

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C20H20N6O4S

[ Molecular Weight ]:
440.476

[ Exact Mass ]:
440.126678

[ LogP ]:
1.57

[ Index of Refraction ]:
1.639

[ Storage condition ]:
2-8℃

Related Compounds