2’-Amino-2’-deoxy-β-D-arabinouridine

Names

[ CAS No. ]:
68115-81-1

[ Name ]:
2’-Amino-2’-deoxy-β-D-arabinouridine

[Synonym ]:
1-(2-Amino-2-deoxy-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 1-(2-amino-2-deoxy-β-D-arabinofuranosyl)-

Biological Activity

[Description]:

2’-Amino-2’-deoxy-β-D-arabinouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C9H13N3O5

[ Molecular Weight ]:
243.22

[ Exact Mass ]:
243.085526

[ LogP ]:
-1.94

[ Index of Refraction ]:
1.617

Related Compounds