ddGTP

Names

[ Name ]:
ddGTP

[Synonym ]:
2',3'-dideoxyguanosine 5'-triphosphoric acid trilithium salt (ddgtp)
2',3'-dideoxyguanosine-5'-triphosphate trisodium salt
2',3'-dideoxyguanosine 5'-triphosphate sodium salt

Biological Activity

[Description]:

ddGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Research Areas >> Others

[References]

[1]. Z G Chidgeavadze, et al. 3'-Fluoro-2',3'-dideoxyribonucleoside 5'-triphosphates: terminators of DNA synthesis. FEBS Lett. 1985 Apr 22;183(2):275-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₆N₅O₁₂P₃

[ Molecular Weight ]:
491.18200

[ Exact Mass ]:
491.00100

[ PSA ]:
288.07000

[ LogP ]:
0.30390

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Selective enzymatic cleavage and labeling for sensitive capillary electrophoresis laser-induced fluorescence analysis of oxidized DNA bases.

J. Chromatogr. A. 1406 , 324-30, (2015)

Oxidatively generated DNA damage is considered to be a significant contributing factor to cancer, aging, and age-related human diseases. It is important to detect oxidatively generated DNA damage to u...

Single methylation of 23S rRNA triggers late steps of 50S ribosomal subunit assembly.

Proc. Natl. Acad. Sci. U. S. A. 112 , E4707-16, (2015)

Ribosome biogenesis requires multiple assembly factors. In Escherichia coli, deletion of RlmE, the methyltransferase responsible for the 2'-O-methyluridine modification at position 2552 (Um2552) in he...

DNA sequencing with chain-terminating inhibitors.

Proc. Natl. Acad. Sci. U. S. A. 74 , 5463, (1977)

A new method for determining nucleotide sequences in DNA is described. It is similar to the "plus and minus" method [Sanger, F. & Coulson, A. R. (1975) J. Mol. Biol. 94, 441-448] but makes use of the ...