3'-O-TERT-BUTYLDIMETHYLSILYLADENOSINE

Names

[ Name ]:
3'-O-TERT-BUTYLDIMETHYLSILYLADENOSINE

[Synonym ]:
O3'-(tert-butyl-dimethyl-silanyl)-adenosine
3'-O-(tert-butyldimethylsilyl)adenosine

Biological Activity

[Description]:

3’-O-t-Butyldimethylsilyladenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₂₇N₅O₄Si

[ Molecular Weight ]:
381.50

[ Exact Mass ]:
381.18300

[ PSA ]:
128.54000

[ LogP ]:
1.63070

3'-O-TERT-BUTYLDIMETHYLSILYLADENOSINE

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds