Swertisin

Names

[ Name ]:
Swertisin

[Synonym ]:
SWERTISIN
SWERTISIN(P)
4H-1-Benzopyran-4-one, 6-(β-D-glucopyranosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-
Sorbifolin 6-O-β-glucopyranoside
apigenin-7-methylether-6-C-glucoside
6-C-glucopyranosyl-7-O-methylapigenin
7-O-methylapigenin mono-6-C-glucoside
5-Hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4-oxo-4H-chromen-6-yl β-D-glucopyranoside

Biological Activity

[Description]:

Swertisin, a C-glucosylflavone isolated from Swertia japonica, is known to have antidiabetic, anti-inflammatory and antioxidant effects. Swertisin is an adenosine A1 receptor antagonist[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Research Areas >> Metabolic Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[References]

[1]. Oh HK, et al. Swertisin ameliorates pre-pulse inhibition deficits and cognitive impairment induced by MK-801 in mice. J Psychopharmacol. 2017 Feb;31(2):250-259.

[2]. Lee HE, et al. Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic property. Behav Brain Res. 2016 Jun 1;306:137-45.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
798.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₂O₁₁

[ Molecular Weight ]:
462.404

[ Flash Point ]:
279.7±26.4 °C

[ Exact Mass ]:
462.116211

[ PSA ]:
179.28000

[ LogP ]:
-1.03

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.695

Swertisin

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds