5-Iminodaunorubicin
Names
[ CAS No. ]:
72983-78-9
[ Name ]:
5-Iminodaunorubicin
Biological Activity
[Description]:
5-Iminodaunorubicin is a quinone-modified anthracycline that retains antitumor activity[1]. 5-Iminodaunorubicin produces protein-concealed DNA strand breaks in cancer cells[2].
[Related Catalog]:
[In Vitro]
In mouse leukemia L1210 cells, 5-Iminodaunorubicin produces protein-concealed DNA strand breaks. Many of the 5-iminodaunorubicin breaks may arise from apposed single-strand breaks (i.e., double-strand breaks)[2].
[In Vivo]
In rat, 5-Iminodaunorubicin (5-ID; 1-16 mg/kg) treatment produces widening of the QRS complex, increased R- and S-wave voltage, and prolonged the Q alpha T interval. And the quinone redox cycling is suppressed in 5-Iminodaunorubicin. 5-Iminodaunorubicin shows lower cardiotoxic[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C27H30N2O9
[ Molecular Weight ]:
526.54