5-Geranoxy-7-methoxycoumarin

5-Geranoxy-7-methoxycoumarin is a coumarin with anti-cancer, antifungal, and  antibacterial activities. 5-Geranoxy-7-methoxycoumarin induces cell apoptosis[1][2].

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Signaling Pathways >> Anti-infection >> Bacterial

5-Geranoxy-7-methoxycoumarin (12.5-200 µM; 24-72 hours) induces a significant inhibition of cell growth in a time-dependent manner in SW480 cells[1]. 5-Geranoxy-7-methoxycoumarin (50 µM;48 hours) promotes DNA fragmentation and causes apoptosis through inhibition of the p38 MAPK signaling pathway in SW480 cells[1]. 5-Geranoxy-7-methoxycoumarin (50 µM; 24-48 hours) increases the percentage of cells in the sub G1/G0 phase from 5.3% (in control cells) to 18% after 48 h incubation[1]. Cell Proliferation Assay[1] Cell Line: SW480 Concentration: 0-20 μM Incubation Time: 24, 48 and 72 hours Result: Inhibited cell growth by 67% at 72 hours. Apoptosis Analysis[1] Cell Line: SW480 cells Concentration: 50 μM Incubation Time: 48 hours Result: Induced cell apoptosis. Cell Cycle Analysis[1] Cell Line: SW480 cells Concentration: 50 μM Incubation Time: 48 hours Result: Inhibited cell cycle progression in vitro.

[1]. Jaiprakash R Patil, et al. 5-Geranyloxy-7-methoxycoumarin inhibits colon cancer (SW480) cells growth by inducing apoptosis. Planta Med. 2013 Mar;79(3-4):219-26.

[2]. Guo-Ying Zuo, et al. Synergism of coumarins from the Chinese drug Zanthoxylum nitidum with antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). Phytomedicine