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((3aR,5R,6S,6aR)-6-Hydroxy-2,2-Dimethyltetrahydrofuro[2,3-D][1,3]Dioxol-5-Yl)Methyl 4-Methylbenzoate

Names

[ CAS No. ]:
75096-60-5

[ Name ]:
((3aR,5R,6S,6aR)-6-Hydroxy-2,2-Dimethyltetrahydrofuro[2,3-D][1,3]Dioxol-5-Yl)Methyl 4-Methylbenzoate

[Synonym ]:
1,2-O-Isopropylidene-5-O-(4-toluoyl)-alpha-D-xylofuranose
1,2-O-ISOPROPYLIDENE-5-O-P-TOLUOYL-A-D-XYLOFURANOSE

Biological Activity

[Description]:

1,2-Di-O-isopropylidene-5-O-(4-methylbenzoyl)-α-D-xylofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C18H24O4

[ Molecular Weight ]:
304.38

[ Exact Mass ]:
308.12600

[ PSA ]:
74.22000

[ LogP ]:
1.38910

Precursor & DownStream

Precursor

DownStream