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Abyssinone V

Names

[ CAS No. ]:
77263-11-7

[ Name ]:
Abyssinone V

[Synonym ]:
Abyssinone-V
5,7-dihydroxy-2-[4-hydroxy-3,5-bis(3-methylbut-2-enyl)phenyl]-2,3-dihydrochromen-4-one

Biological Activity

[Description]:

Abyssinone V is a prenylated flavonoid with predicted anti-viral activity. Abyssinone V can be isolated from the stem bark of Erythrina melanacantha. Abyssinone V possesses good pharmacodynamics properties. Abyssinone V is predicted to be antivirals including anti-herpes (HSV) agent, with mechanisms comprising inhibition of polymerase, ATPase and membrane integrity[1][2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HSV
Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Signaling Pathways >> Membrane Transporter/Ion Channel >> ATP Synthase

[References]

[1]. Koch K, et al. Abyssinone V, a prenylated flavonoid isolated from the stem bark of Erythrina melanacantha increases oxidative stress and decreases stress resistance in Caenorhabditis elegans. J Pharm Pharmacol. 2019 Jun;71(6):1007-1016.  

[2]. Kwofie SK, et al. Identification of novel potential inhibitors of varicella-zoster virus thymidine kinase from ethnopharmacologic relevant plants through an in-silico approach. J Biomol Struct Dyn. 2022;40(23):12932-12947.  

Chemical & Physical Properties

[ Density]:
1.22g/cm3

[ Boiling Point ]:
619.8ºC at 760 mmHg

[ Molecular Formula ]:
C25H28O5

[ Molecular Weight ]:
408.49

[ Flash Point ]:
210.8ºC

[ Exact Mass ]:
408.19400

[ PSA ]:
86.99000

[ LogP ]:
5.52730

[ Index of Refraction ]:
1.615

Related Compounds