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6-O-Methyl Guanosine

Names

[ CAS No. ]:
7803-88-5

[ Name ]:
6-O-Methyl Guanosine

[Synonym ]:
9H-Purin-2-amine, 6-methoxy-9-β-D-ribofuranosyl-
6-O-METHYLGUANOSINE
Guanosine,o-methyl
2-amino-6-methoxypurine riboside
6-Methoxy-6-deoxoguanosine
o-methoxydeoxyguanosine
O-Methylguanosine
6-Methoxy-9-(β-D-ribofuranosyl)-9H-purin-2-amine
O6-METHYLGUANOSINE
o-methyl-guanosin
2-Amino-6-methoxypurine Ribonucleoside

Biological Activity

[Description]:

6-O-Methyl Guanosine is a modified nucleoside[1]. 6-O-Methyl Guanosine (6-methylguanosine) inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line[2].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Inflammation/Immunology

[References]

[1]. Grasby JA, et al. The synthesis of oligoribonucleotides containing O6-methylguanosine: the role of conserved guanosine residues in hammerhead ribozyme cleavage. Nucleic Acids Res. 1993 Sep 25;21(19):4444-50.

[2]. Thielmann HW, et al. 6-Methylguanine and 6-methylguanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line but not in other xeroderma pigmentosum and normal human fibroblast strains after treatment with 1-(2-chloroethyl)-1-nitroso-3-(2-hydroxyethyl)-urea. J Cancer Res Clin Oncol. 1987;113(1):67-72.

Chemical & Physical Properties

[ Density]:
2.0±0.1 g/cm3

[ Boiling Point ]:
721.0±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H15N5O5

[ Molecular Weight ]:
297.267

[ Flash Point ]:
389.9±35.7 °C

[ Exact Mass ]:
297.107330

[ PSA ]:
148.77000

[ LogP ]:
-0.58

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.829

[ Storage condition ]:
2-8℃

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MF8790000
CHEMICAL NAME :
Guanosine, O-methyl-
CAS REGISTRY NUMBER :
7803-88-5
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H15-N5-O5
MOLECULAR WEIGHT :
297.31
WISWESSER LINE NOTATION :
T56 BN DN FVN INJ HZ B- BT5OTJ CO1 DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
2400 nmol/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 4,321,1982

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds