2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine

Names

[ Name ]:
2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine

[Synonym ]:
2(1H)-Pyrimidinone,4-amino-1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-ethyl

Biological Activity

[Description]:

2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

Research Areas >> Others

[References]

[1]. Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3(11):1062-8.

Chemical & Physical Properties

[ Density]:
1.73 g/cm3

[ Boiling Point ]:
495.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₄FN₃O₄

[ Molecular Weight ]:
259.23

[ Flash Point ]:
253.4ºC

[ Exact Mass ]:
275.09200

[ PSA ]:
127.70000

[ Index of Refraction ]:
1.674

2′-Deoxy-2′-fluoro-5-methyl-arabinocytidine

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds