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6-dimethylamino-2'-deoxyguanosine

Names

[ CAS No. ]:
83061-20-5

[ Name ]:
6-dimethylamino-2'-deoxyguanosine

[Synonym ]:
Adenosine, 2-amino-2'-deoxy-N,N-dimethyl-
2-Amino-2'-deoxy-N,N-dimethyladenosine

Biological Activity

[Description]:

2-Amino-2’-deoxy-N6,N6-dimethyl-2’-adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
665.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C12H18N6O3

[ Molecular Weight ]:
294.31

[ Flash Point ]:
356.4±34.3 °C

[ Exact Mass ]:
294.144043

[ LogP ]:
-0.01

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.776

Related Compounds