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116-9e

Names

[ CAS No. ]:
831217-43-7

[ Name ]:
116-9e

[Synonym ]:
upcmld00wmal2-11b
hms2227g12
upcmld00wmal2-11b:004
upcmld00wmal2-11b:002
upcmld00wmal2-11b:003

Biological Activity

[Description]:

116-9e (MAL2-11B) is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis. 116-9e inhibits tumor antigen (TAg)’s endogenous ATPase activity and the TAg-mediated activation of Hsp70[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> HSP
Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

[Target]

Simian Virus 40 (SV40) [1] Hsp70 co-chaperone DNAJA1[2]


[In Vitro]

116-9e (MAL2-11B) inhibits TAg stimulation of Hsp70 with greater efficacy than MAL3-101, significantly reduces viral replication and DNA synthesis. MAL2-11B also inhibits the activity of the TAg ATPase domain[1]. 116-9e (MAL2-11B; 15 µM; 5 days) significantly reduces the growth of BK virus in a human kidney cell line[1].

[References]

[1]. Christine M Wright, et al. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Res. 2009 Apr;141(1):71-80.

[2]. Nitika, et al. Chemogenomic screening identifies the Hsp70 co-chaperone DNAJA1 as a hub for anticancer drug resistance. Sci Rep. 2020 Aug 14;10(1):13831.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H32N2O5

[ Molecular Weight ]:
512.60

[ Exact Mass ]:
512.23100

[ PSA ]:
99.43000

[ LogP ]:
5.66020

[ Storage condition ]:
2-8°C

MSDS

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Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H410

[ Precautionary Statements ]:
P273-P301 + P310-P501

[ Hazard Codes ]:
T

[ Risk Phrases ]:
25-50/53

[ Safety Phrases ]:
45-60-61

[ RIDADR ]:
UN 2811 6.1 / PGIII

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds