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BRD-6929

Names

[ CAS No. ]:
849234-64-6

[ Name ]:
BRD-6929

[Synonym ]:
4-(acetylamino)-n-[2-amino-5-(2-thienyl)phenyl]-benzamide

Biological Activity

[Description]:

BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50= 1 and 8 nM), extracted from patent US2018360927[1]. BRD-6929 (Cpd-60) shows high-affinity to HDAC1 and HDAC2 with Ki of 0.2 and 1.5 nM, respectively[2]. BRD-6929 (TPB) potentiates the efficacy of gnidimacrin (a PKC Agonist) against latent HIV-1[3].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC
Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC1:1 nM (IC50)

HDAC2:8 nM (IC50)

HIV


[References]

[1]. Li-Huei Tsai, et al. Inhibition of hdac2 to promote memory. patent/US20120101147

[2]. Schroeder FA, et al. A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and altersmouse behavior in two mood-related tests. PLoS One. 2013 Aug 14;8(8):e71323.

[3]. Huang L, et al. Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. ACS Med Chem Lett. 2018 Feb 6;9(3):268-273.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H17N3O2S

[ Molecular Weight ]:
351.42200

[ Exact Mass ]:
351.10400

[ PSA ]:
112.46000

[ LogP ]:
4.93520

Related Compounds