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6H-Purin-6-one,2-amino-9-(6-deoxy-b-D-allofuranosyl)-1,9-dihydro-

Names

[ CAS No. ]:
85421-89-2

[ Name ]:
6H-Purin-6-one,2-amino-9-(6-deoxy-b-D-allofuranosyl)-1,9-dihydro-

Biological Activity

[Description]:

5’(R)-C-Methylguanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

[2]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.  

Chemical & Physical Properties

[ Density]:
2.11g/cm3

[ Boiling Point ]:
744.3ºC at 760 mmHg

[ Molecular Formula ]:
C11H15N5O5

[ Molecular Weight ]:
297.27

[ Flash Point ]:
403.9ºC

[ Exact Mass ]:
297.10700

[ PSA ]:
159.51000

[ Index of Refraction ]:
1.895

Related Compounds