LT175

Names

[ Name ]:
LT175

[Synonym ]:
Benzenepropanoic acid, α-([1,1'-biphenyl]-4-yloxy)-, (αS)-
(2S)-2-(4-Biphenylyloxy)-3-phenylpropanoic acid
MFCD28386029
(2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid

Biological Activity

[Description]:

LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ(hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm). LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1). LT175 interacts with PPARγ in a hydrophobic region called “diphenyl pocket”. LT175 has potent insulin-sensitizing effects and reduced adipogenic properties[1].

[Related Catalog]:

Research Areas >> Endocrinology

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

Research Areas >> Metabolic Disease

[Target]

hPPARα:0.22 μM (EC50)

mPPARα:0.26 μM (EC50)

hPPARγ:0.48 μM (EC50)

[In Vivo]

LT175 (100 mg/kg/day; orally; for 3 days) induces a significant decrease in body weight (11%) and reduces fasting blood glucose, triglycerides, and free fatty acids. LT175 decreases total plasma cholesterol significantly in diet-induced Insulin-resistant mice (six-week-old C57Bl/6J male mice)[1].

[References]

[1]. Federica Gilardi, et al. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. J Biol Chem. 2014 Mar 7;289(10):6908-6920.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
509.8±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₈O₃

[ Molecular Weight ]:
318.366

[ Flash Point ]:
182.3±22.2 °C

[ Exact Mass ]:
318.125580

[ LogP ]:
4.90

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.611

Safety Information

[ Symbol ]:

GHS06, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H410

[ Precautionary Statements ]:
P273-P301 + P310 + P330-P391-P501

[ RIDADR ]:
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all