N-ALPHA-PALMITOYL-S-[2,3-BIS(PALMITOYLOXY)-(2RS)-PROPYL]-L-CYSTEINE

Names

[ CAS No. ]:
87420-41-5

[ Name ]:
N-ALPHA-PALMITOYL-S-[2,3-BIS(PALMITOYLOXY)-(2RS)-PROPYL]-L-CYSTEINE

[Synonym ]:
MFCD00153468

Biological Activity

[Description]:

Pam3-Cys-OH is a synthetic bacterial lipoprotein[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Hasegawa M, et al. Transitions in oral and intestinal microflora composition and innate immune receptor-dependent stimulation during mouse development. Infect Immun. 2010 Feb;78(2):639-50.

Chemical & Physical Properties

[ Density]:
0.966g/cm3

[ Boiling Point ]:
907.8ºC at 760 mmHg

[ Molecular Formula ]:
C₅₄H₁₀₃NO₇S

[ Molecular Weight ]:
910.46300

[ Flash Point ]:
502.8ºC

[ Exact Mass ]:
909.74600

[ PSA ]:
144.30000

[ LogP ]:
16.57880

[ Index of Refraction ]:
1.482

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Chronic pulmonary LPS tolerance induces selective immunosuppression while maintaining the neutrophilic response.

Shock 33(2) , 162-9, (2010)

LPS challenge causes potent activation of innate immunity. Because LPS is ubiquitously present in ambient air, repeated inhalation may lead to activation of the pulmonary immune response. If this acti...

Attenuated pathogenesis of polymicrobial peritonitis in mice after TLR2 agonist pre-treatment involves ST2 up-regulation.

Int. Immunol. 17(8) , 1035-46, (2005)

The innate immune system uses Toll-like receptors (TLRs) to activate and instruct immune responses against microbial pathogens. Administration of TLR agonists to mice induces a state of hyporesponsive...

Improved intranasal immunization with live-attenuated measles virus after co-inoculation of the lipopeptide MALP-2.

Vaccine 23(39) , 4721-6, (2005)

The macrophage-activating lipopeptide with a molecular weight of 2kDa (MALP-2) activates antigen presenting cells of human, mouse and rat origin in vitro and in vivo. Here, we demonstrate that MALP-2 ...