TG693

Names

[ Name ]:
TG693

[Synonym ]:
INDAZOLE,5-(4-PYRIDINYL)
5-(4-Pyridinyl)-1H-indazole
5-(Pyridin-4-yl)-1H-indazole
1H-Indazole,5-(4-pyridinyl)

Biological Activity

[Description]:

TG693 is an orally active inhibitor of CLK1. TG693 regulates the mutated exon 31 of the dystrophin gene in vivo. TG693 is used in Duchenne muscular dystrophy (DMD) research[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[References]

[1]. Sako Y, et al. Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy. Sci Rep. 2017 May 30;7:46126.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₉N₃

[ Molecular Weight ]:
195.22

[ Exact Mass ]:
195.08000

[ PSA ]:
41.57000

[ LogP ]:
2.62490

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%