5-[[Methyl(2,2,2-trifluoroacetyl)amino]methyl]-2-thiouridine

Names

[ CAS No. ]:
89128-99-4

[ Name ]:
5-[[Methyl(2,2,2-trifluoroacetyl)amino]methyl]-2-thiouridine

[Synonym ]:
N-[1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydro-pyrimidin-5-ylmethyl]-2,2,2-trifluoro-N-methyl-acetamide
N-methyl-N-TFA-aminomethyl-2-thiouridine

Biological Activity

[Description]:

5-[[Methyl(2,2,2-trifluoroacetyl)amino]methyl]-2-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C13H16F3N3O6S

[ Molecular Weight ]:
399.34

[ Exact Mass ]:
399.07100

[ PSA ]:
160.11000

Related Compounds