XR-5000

Names

[ Name ]:
XR-5000

[Synonym ]:
Acridine carboxamide
N-(2-(Dimethylamino)ethyl)-4-acridinecarboxamide
N-(2-(Dimehtylamino)ehtyl)acridine-4-carboxamide
Daca
4-Acridinecarboxamide,N-(2-(dimethylamino)ethyl)
N-[2-(Dimethyl-amino)ethyl]acridine-4-carboxamide

Biological Activity

[Description]:

DACA inhibits two essential nuclear enzymes in vitro, DNA topoisomerase I and DNA topoisomerase (topo) II. DACA stabilises topo I, topo II alpha, and topo II beta cleavable complexes in human leukaemia CCRF-CEM cells[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase

[References]

[1]. Padget K, et al. An investigation into the formation of N- [2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and 6-[2-(dimethylamino)ethylamino]- 3-hydroxy-7H-indeno[2, 1-C]quinolin-7-one dihydrochloride (TAS-103) stabilised DNA topoisomerase I and II cleavable complexes in human leukaemia cells. Biochem Pharmacol. 2000;60(6):817-821.

Chemical & Physical Properties

[ Density]:
1.182g/cm3

[ Boiling Point ]:
544.1ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₁₉N₃O

[ Molecular Weight ]:
293.36300

[ Flash Point ]:
282.9ºC

[ Exact Mass ]:
293.15300

[ PSA ]:
48.72000

[ LogP ]:
3.25420

[ Index of Refraction ]:
1.657

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR7622610

CHEMICAL NAME :: 4-Acridinecarboxamide, N-(2-(dimethylamino)ethyl)-

CAS REGISTRY NUMBER :: 89459-25-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C18-H19-N3-O

MOLECULAR WEIGHT :: 293.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 44597 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 150 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 268,35,1992