2',3'-O-isopropylidene-5-pyrrolidinomethyl-2-thiouridine

Names

[ Name ]:
2',3'-O-isopropylidene-5-pyrrolidinomethyl-2-thiouridine

[Synonym ]:
1-((3aR,4R,6R,6aR)-6-Hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-5-pyrrolidin-1-ylmethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one

Biological Activity

[Description]:

2',3'-O-Isopropylidene-5-pyrrolidinomethyl-2-thiouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₅N₃O₅S

[ Molecular Weight ]:
383.46

[ Exact Mass ]:
383.15100

[ PSA ]:
121.04000

[ LogP ]:
0.84940