M871

Names

[ Name ]:
M871

[Synonym ]:
trp-thr-leu-asn-ser-ala-gly-tyr-leu-leu-gly-pro-glu-his-pro-pro-pro-ala-leu-ala-leu-ala-nh2

Biological Activity

[Description]:

M871 (Galanin-(2-13)-Glu-His-(Pro)3-(Ala-Leu)2-Ala-amide) is a selective galanin receptor type 2 (GalR2) antagonist. M871 exhibits Ki values of 13.1 nM and 420 nM for GalR2 and GalR1, respectively. M871 can be used for research on GalR2-related diseases (such as epilepsy, pain)[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[Target]

GalR2[1].

[References]

[1]. U. E. Sollenberg, et al. M871—A Novel Peptide Antagonist Selectively Recognizing the Galanin Receptor Type 2. Int J Pept Res Ther. 2006;12:2965-2982.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀₈H₁₆₃N₂₇O₂₈

[ Molecular Weight ]:
2287.61

[ Exact Mass ]:
2286.22000

[ PSA ]:
830.60000

[ LogP ]:
2.82670

[ Storage condition ]:
-20°C

M871

Names

Biological Activity

Chemical & Physical Properties

Related Compounds