EC 144
Names
[ CAS No. ]:
911397-80-3
[ Name ]:
EC 144
[Synonym ]:
5-[2-Amino-4-chloro-7-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2-methyl-4-pentyn-2-ol
Biological Activity
[Description]:
EC144 is a potent and selective inhibitor of heat shock protein 90 (Hsp90) with an IC50 of 1.1 nM. EC144 inhibits tumor growth and causes partial tumor regressions. EC144 has the potential for the research of cancer diseases[1].
[Related Catalog]:
[References]
Chemical & Physical Properties
[ Density]:
1.29±0.1 g/cm3(20 °C , 760mmHg)
[ Boiling Point ]:
674.1±65.0 °C (760 mmHg)
[ Molecular Formula ]:
C21H24ClN5O2
[ Molecular Weight ]:
413.90100
[ Exact Mass ]:
413.16200
[ PSA ]:
99.08000
[ LogP ]:
3.82930