Tefinostat

Names

[ Name ]:
Tefinostat

[Synonym ]:
Tefinostat

Biological Activity

[Description]:

Tefinostat (CHR-2845) is a monocyte/macrophage-targeted pan HDAC inhibitor, cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Anti-monocytoid lineage leukaemias activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC

Signaling Pathways >> Epigenetics >> HDAC

[Target]

HDAC

[References]

[1]. Zabkiewicz J, et al. The targeted histone deacetylase inhibitor tefinostat (CHR-2845) shows selective in vitro efficacy in monocytoid-lineage leukaemias. Oncotarget. 2016 Mar 29;7(13):16650-62.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₈H₃₇N₃O₅

[ Molecular Weight ]:
495.61000

[ Exact Mass ]:
495.27300

[ PSA ]:
120.25000

[ LogP ]:
6.09200