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DUBs-IN-2

Names

[ CAS No. ]:
924296-19-5

[ Name ]:
DUBs-IN-2

[Synonym ]:
9-Ethoxyimino-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
DUBs-IN-2

Biological Activity

[Description]:

DUBs-IN-2 is a potent deubiquitinase inhibitor with an IC50 of 0.28 μM for USP8.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase
Research Areas >> Cancer

[Target]

IC50: 0.28 μM (USP8)[1]


[In Vitro]

DUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC50 of 0.28 μM, and has no effect on USP7, with an IC50 of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC50 values of 0.5-1.5 μM[1].

[References]

[1]. Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.


[Related Small Molecules]

BAY 11-7082 | P5091 | PR-619 | VLX1570 | Degrasyn(WP1130) | P 22077 | ML364 | NSC 687852 | GNE-6776 | ML 323 | HBX 19818 | IU1 | LDN-57444 | USP7/USP47 inhibitor

Chemical & Physical Properties

[ Density]:
1.36±0.1 g/cm3 (20 °C, 760 mmHg)

[ Boiling Point ]:
555.7±60.0 °C (760 mmHg)

[ Molecular Formula ]:
C15H9N5O

[ Molecular Weight ]:
275.26500

[ Exact Mass ]:
275.08100

[ PSA ]:
94.95000

[ LogP ]:
1.98926

Related Compounds