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DB07268

Names

[ CAS No. ]:
929007-72-7

[ Name ]:
DB07268

[Synonym ]:
Benzamide, 2-[[2-[(3-hydroxyphenyl)amino]-4-pyrimidinyl]amino]-
2-({2-[(3-Hydroxyphenyl)amino]-4-pyrimidinyl}amino)benzamide
MFCD26960941
DB07268

Biological Activity

[Description]:

DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM.

[Related Catalog]:

Signaling Pathways >> MAPK/ERK Pathway >> JNK
Research Areas >> Cancer

[Target]

JNK1:9 nM (IC50)

CHK1:0.82 μM (IC50)

PAK4:5.5 μM (IC50)

AKT1:15 μM (IC50)

ERK2:25 μM (IC50)


[In Vitro]

DB07268 (Compound 2b) also inhibits CHK1, PAK4, AKT1, and ERK2 with IC50s of 0.82 μM, 5.5 μM, 15 μM, and 25 μM, respectively[1].

[References]

[1]. Liu M, et al. Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies. Bioorg Med Chem Lett. 2007 Feb 1;17(3):668-72.


[Related Small Molecules]

Pyrazolanthrone (SP600125) | JNK-IN-8 | Tomatidine | CC-930 | Astragaloside IV | D-JNKI-1 | AS601245 | JNK-IN-7 | BI 78D3 | SR-3306 | Bentamapimod | CC-401 | Ginsenoside Re | Isovitexin | Juglanin

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
641.6±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H15N5O2

[ Molecular Weight ]:
321.333

[ Flash Point ]:
341.8±34.3 °C

[ Exact Mass ]:
321.122589

[ LogP ]:
1.96

[ Appearance of Characters ]:
light yellow solid

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.753

[ Storage condition ]:
-20°C

Related Compounds