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N6-Benzoyl-7’-OH-N-trityl morpholino adenine

Names

[ CAS No. ]:
956139-16-5

[ Name ]:
N6-Benzoyl-7’-OH-N-trityl morpholino adenine

[Synonym ]:
MFCD22666304
N-{9-[(2R,6S)-6-(Hydroxymethyl)-4-trityl-2-morpholinyl]-9H-purin-6-yl}benzamide
Benzamide, N-[9-[(2R,6S)-6-(hydroxymethyl)-4-(triphenylmethyl)-2-morpholinyl]-9H-purin-6-yl]-

Biological Activity

[Description]:

N6-Benzoyl-7’-OH-N-trityl morpholino adenine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C36H32N6O3

[ Molecular Weight ]:
596.68

[ Exact Mass ]:
596.253601

[ LogP ]:
6.14

[ Index of Refraction ]:
1.686

Related Compounds