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2'-DEOXYGUANOSINE 5'-TRIPHOSPHATE DILITHIUM SALT

Names

[ CAS No. ]:
95648-75-2

[ Name ]:
2'-DEOXYGUANOSINE 5'-TRIPHOSPHATE DILITHIUM SALT

[Synonym ]:
einecs 306-016-7

Biological Activity

[Description]:

dGTP-15N5 (2'-Deoxyguanosine-5'-triphosphate-15N5) dilithium is 15N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H14Li2N5O13P3

[ Molecular Weight ]:
519.04700

[ Exact Mass ]:
519.01200

[ PSA ]:
313.96000

[ LogP ]:
0.15110

Safety Information

[ Safety Phrases ]:
22-24/25

[ WGK Germany ]:
3

Related Compounds