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5-Hydroxyuridine

Names

[ CAS No. ]:
957-77-7

[ Name ]:
5-Hydroxyuridine

[Synonym ]:
5-Hydroxy-uridin
5-Hydroxy-uracil-ribotid
Uridine, 5-hydroxy-
Uridine,5-hydroxy
5-hydroxy-uridine
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-5-hydroxy-pyrimidine-2,4-quinone
5-Hydroxyuridine
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-pyrimidine-2,4-dione

Biological Activity

[Description]:

5-Hydroxyuridine (OHUrd) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Molecular Formula ]:
C9H12N2O7

[ Molecular Weight ]:
260.20

[ Exact Mass ]:
260.064453

[ PSA ]:
145.01000

[ LogP ]:
-1.51

[ Index of Refraction ]:
1.698

[ Storage condition ]:
2-8°C

Synthetic Route

Click to get detail synthetic route

Related Compounds