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Nyasol

Names

[ CAS No. ]:
96895-25-9

[ Name ]:
Nyasol

[Synonym ]:
4,4'-(3-Ethenyl-1-propene-1,3-diyl)-bisphenol
(+)-hinokiresinol
Nyasol

Biological Activity

[Description]:

Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> GPCR/G Protein >> Leukotriene Receptor
Signaling Pathways >> Anti-infection >> Fungal
Signaling Pathways >> Immunology/Inflammation >> NO Synthase
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Lim H, et al. (-)-Nyasol (cis-hinokiresinol), a norneolignan from the rhizomes of Anemarrhena asphodeloides, is a broad spectrum inhibitor of eicosanoid and nitric oxide production. Arch Pharm Res. 2009 Nov;32(11):1509-14.  

[2]. Iida Y, et al. In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans. Planta Med. 2000 Jun;66(5):435-8.  

[3]. Lee HJ, et al. (-)-Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-κBα degradation in LPS-stimulated BV-2 microglial cells. J Enzyme Inhib Med Chem. 2013 Oct;28(5):954-9.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H16O2

[ Molecular Weight ]:
252.31

[ Exact Mass ]:
252.11500

[ PSA ]:
40.46000

[ LogP ]:
4.08080

Related Compounds