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2'-Azido-2'-deoxy-5-methyluridine

Names

[ CAS No. ]:
97748-75-9

[ Name ]:
2'-Azido-2'-deoxy-5-methyluridine

[Synonym ]:
2'-AZIDO-2'-DEOXY-5-METHYLURIDINE
1-[(2R,3R,4S,5R)-3-azido-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
2'-Azido-2'-deoxy-5-methyl uridine
URIDINE, 2'-AZIDO-2'-DEOXY-5-METHYL-
2'-Deoxy-2'-azidoribothymidine

Biological Activity

[Description]:

2′-Azido-2′-deoxy-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C10H13N5O5

[ Molecular Weight ]:
283.24

[ Exact Mass ]:
283.09200

[ PSA ]:
154.30000

Related Compounds