6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine

Names

[ CAS No. ]:
100644-69-7

[ Name ]:
6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine

[Synonym ]:
8-aza-7-deaza-2'-deoxy-O-methylguanosine
6-Amino-1-(2'-deoxy-β-D-erythro-pentofuranosyl)-4-methoxy-1H-pyrazolo<3,4-d>pyrimidine
6-amino-1-(2'-deoxy-β-D-erythro-pentofuranosyl)-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine

Biological Activity

[Description]:

6-Amino-4-methoxy-1-(2-deoxy-β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Galmarini CM, et al. Pyrimidine nucleoside analogs in cancer treatment. Expert Rev Anticancer Ther. 2003 Oct;3(5):717-28.  

Chemical & Physical Properties

[ Molecular Formula ]:
C11H15N5O4

[ Molecular Weight ]:
281.27

[ Exact Mass ]:
281.11200

[ PSA ]:
128.54000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds