5′-O-[Bis(4-methoxyphenyl)phenylmethyl]cytidine

Names

[ CAS No. ]:
112897-99-1

[ Name ]:
5′-O-[Bis(4-methoxyphenyl)phenylmethyl]cytidine

[Synonym ]:
5'-O-(4,4'-dimethoxytrityl)-cytidine
Uridine,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3-methyl
5'-O-(4,4'-dimethoxytrityl)-3-methyluridine

Biological Activity

[Description]:

5′-O-[Bis(4-methoxyphenyl)phenylmethyl]cytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.34

[ Boiling Point ]:
742.535ºC at 760 mmHg

[ Molecular Formula ]:
C30H31N3O7

[ Molecular Weight ]:
545.58

[ Exact Mass ]:
545.21600

[ PSA ]:
139.28000

[ LogP ]:
2.81300

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream