CDK4/6-IN-16

Names

[ CAS No. ]:
1169694-98-7

[ Name ]:
CDK4/6-IN-16

[Synonym ]:
Ethanol, 2-[[[1-[6-[(9-cyclopentyl-8-fluoro-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-4-piperidinyl]methyl]amino]-
2-{[(1-{6-[(9-Cyclopentyl-8-fluoro-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl}-4-piperidinyl)methyl]amino}ethanol

Biological Activity

[Description]:

CDK4/6-IN-16 (example 195) is a potent CDK4 and CDK6 inhibitor, with an IC50 of 0.013 μM for CDK4. CDK4/6-IN-16 can be used for the research of CDK4-mediated disorders, such as cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK4:13 nM (IC50)

CDK6


[References]

[1]. Richard V. Connors, et al. Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors. WO2009085185A1.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
729.5±70.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H33FN8O

[ Molecular Weight ]:
504.602

[ Flash Point ]:
395.0±35.7 °C

[ Exact Mass ]:
504.276123

[ LogP ]:
1.86

[ Vapour Pressure ]:
0.0±2.5 mmHg at 25°C

[ Index of Refraction ]:
1.735

Related Compounds