Melittin (free acid) trifluoroacetate salt

Names

[ CAS No. ]:
123168-46-7

[ Name ]:
Melittin (free acid) trifluoroacetate salt

[Synonym ]:
L-Glutamine, glycyl-L-isoleucylglycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-threonyl-L-threonylglycyl-L-leucyl-L-prolyl-L-alanyl-L-leucyl-L-isoleucyl-L-seryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl-
Glycyl-L-isoleucylglycyl-L-alanyl-L-valyl-L-leucyl-L-lysyl-L-valyl-L-leucyl-L-threonyl-L-threonylglycyl-L-leucyl-L-prolyl-L-alanyl-L-leucyl-L-isoleucyl-L-seryl-L-tryptophyl-L-isoleucyl-L-lysyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminyl-L-glutamine

Biological Activity

[Description]:

Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Infection
Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase
Signaling Pathways >> Anti-infection >> Fungal

[In Vitro]

Melittin free acid 刺激小鼠纤维细胞 (MC5-5)、人成纤维细胞 (D550)、兔主动脉内皮细胞 (CLO)、大鼠肺型肺泡肺细胞 (L-2) 和兔平滑肌细胞 (R-I) 的前列腺素生物合成[1]。 Melittin free acid 刺激 MC5-5 细胞磷脂中花生四烯酸的释放[1]。 Melittin free acid 诱导黄曲霉萌发分生孢子中活性氧的积累[2]。 Melittin 抑制灰霉菌 MUCL 30158 和 CECT 2100 菌株，IC50 值分别为 3.1 和 24 μM[2]。

[In Vivo]

Melittin (腹腔内接种) 可增加小鼠外周血中 13,14-dihydro-15-keto-PGE2 的水平[1]。

[References]

[1]. Hassid A, Levine L. Stimulation of phospholipase activity and prostaglandin biosynthesis by melittin in cell culture and in vivo. Res Commun Chem Pathol Pharmacol. 1977.  

[2]. Memariani H, Memariani M. Anti-fungal properties and mechanisms of melittin. Appl Microbiol Biotechnol. 2020 Aug;104(15):6513-6526.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C131H228N38O32

[ Molecular Weight ]:
2847.448

[ Exact Mass ]:
2845.738281

[ LogP ]:
-0.28

[ Index of Refraction ]:
1.634

Related Compounds