JNK-1-IN-1

Names

[ CAS No. ]:
1262406-02-9

[ Name ]:
JNK-1-IN-1

Biological Activity

[Description]:

JNK-1-IN-1 is a JNK-1 inhibitor. JNK-1-IN-1 also inhibits MKK7 with an IC50 of 7.8μM. JNK-1-IN-1 bind to MKK7cp and acts as an inhibitor of JNK-1[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> MAPK/ERK Pathway >> JNK

[Target]

JNK1


[In Vitro]

JNK-1-IN-1 (Compound 2) 对 HepG2 人肝癌细胞中的 Jnk1-u、p38α-u、ERK2-u 具有亲和力，Kd 值分别为 11、18、18[1]。 JNK-1-IN-1 抑制 HepG2 人肝癌细胞中的 MKK7cp，IC50 值为 7.8[1]。

[References]

[1]. Comess KM, et al. Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases. ACS Chem Biol. 2011 Mar 18;6(3):234-44.  

Chemical & Physical Properties

[ Molecular Formula ]:
C24H22N6S

[ Molecular Weight ]:
426.53700

[ Exact Mass ]:
426.16300

[ PSA ]:
98.83000

[ LogP ]:
5.56000

Related Compounds